Application

Anti-PECAM-1, C-Terminal antibody produced in rabbit has been used in immunohistochemistry.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)

Biochem/physiol Actions

Platelet and endothelial cell adhesion molecule 1 (PECAM1) also called as cluster of differentiation 31 (CD31), plays a crucial role in the adhesion cascade leading to leukocyte extravasation during the inflammatory process. PECAM1 is essential for leukocyte transmigration via intercellular junctions of vascular endothelial cells. Genetic polymorphism of PECAM1 is associated with atherosclerotic events. PECAM1, is a membrane glycoprotein that facilitates both homophilic and heterophilic adhesion. PECAM1 is also implicated in angiogenesis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

The platelet and endothelial cell adhesion molecule 1 (PECAM1) gene, spanning 75-kb, is mapped on the long arm of human chromosome 17. This gene codes for 130-kD protein, which belongs to the immunoglobulin (Ig) superfamily. It is a vital component of the endothelial cell intercellular junction. PECAM1 is expressed on the surface of circulating platelets, monocytes, neutrophils and selected T-cell subsets.

Anti-PECAM-1 Antibody detects endogenous levels of total PECAM-1 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human PECAM-1.Immunogen Range: 686-735

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.